Successful treatment of meticillin-resistant Staphylococcus aureus bacteraemia in a neonate using daptomycin.
نویسندگان
چکیده
Daptomycin is licensed for the management of Staphylococcus aureus infections in adults, including those caused by meticillin-resistant S. aureus (MRSA). Few data exist on paediatric use or dose guidance in neonates. We report the case of a neonate with MRSA bacteraemia successfully managed with daptomycin. Dose requirements were substantially higher than those recommended for adults.
منابع مشابه
Successful treatment of methicillin-resistant Staphylococcus aureus mitral valve endocarditis with sequential linezolid and telavancin monotherapy following daptomycin failure.
Sir, We read with great interest the case report by Joson et al. in which they describe the successful treatment of methicillinresistant Staphylococcus aureus (MRSA) mitral valve endocarditis with sequential linezolid and telavancin monotherapy, following daptomycin failure. However, we would like to comment on the antimicrobial course and dosing. This report relates to a case of bacteraemia th...
متن کاملDaptomycin versus vancomycin plus gentamicin for treatment of bacteraemia and endocarditis due to Staphylococcus aureus: subset analysis of patients infected with methicillin-resistant isolates
OBJECTIVES In a prospective, randomized trial, daptomycin was non-inferior to standard therapy for Staphylococcus aureus bacteraemia and right-sided endocarditis. Since rates of infection due to methicillin-resistant S. aureus (MRSA) infection are increasing and treatment outcomes for bacteraemia caused by MRSA are generally worse than those observed with methicillin-susceptible S. aureus bacte...
متن کاملCommunity-Associated Methicillin-Resistant Staphylococcus Aureus Orbital Cellulitis in a Neonate. Staphylococcus Aureus Orbital Cellulitis in a Neonate
Background Methicillin-resistant Staphylococcus aureus is a serious cause of morbidity and mortality in hospital environment, but also, lately, in the community. This case report is, in our knowledge, the first detailed description of a community aquires Methicillinresistant Staphylococcus aureus ST80 orbital cellulitis in a previously healthy neonate. Possible predisposing factors of microbial...
متن کاملIn vitro activity of daptomycin and comparator agents against Staphylococcus aureus isolates from intravenous drug users with right endocarditis.
There is an increasing need for alternative agents in endocarditis, especially with the increasing incidence of vancomycin-intermediate Staphylococcus aureus (VISA). We evaluated the in vitro activity of daptomycin and several comparator agents against 33 non-duplicate clinical Staphylococcus aureus isolates from intravenous drug users with right endocarditis. Wider microdilution panels were us...
متن کاملDaptomycin for endocarditis and/or bacteraemia: a systematic review of the experimental and clinical evidence.
BACKGROUND Endocarditis and bacteraemia are devastating infections with high mortality. Gram-positive cocci are the most commonly isolated pathogens. In an era of multidrug-resistant pathogens, the evaluation of new treatment options is important. Daptomycin is a cyclic lipopeptide that is active against most of these pathogens. Furthermore, it is a bactericidal antibiotic, a factor that is fre...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of medical microbiology
دوره 60 Pt 3 شماره
صفحات -
تاریخ انتشار 2011